Increasing value and reducing waste in biomedical research: who's listening?
Identifieur interne : 001C83 ( Main/Exploration ); précédent : 001C82; suivant : 001C84Increasing value and reducing waste in biomedical research: who's listening?
Auteurs : David Moher [Canada] ; Paul Glasziou [Australie] ; Iain Chalmers [Royaume-Uni] ; Mona Nasser [Royaume-Uni] ; Patrick M M. Bossuyt [Pays-Bas] ; Daniël A. Korevaar [Pays-Bas] ; Ian D. Graham [Canada] ; Philippe Ravaud [France] ; Isabelle Boutron [France]Source :
- Lancet (London, England) [ 1474-547X ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- standards : Biomedical Research, Research Design.
- Cooperative Behavior, Humans, Research Personnel.
Abstract
The biomedical research complex has been estimated to consume almost a quarter of a trillion US dollars every year. Unfortunately, evidence suggests that a high proportion of this sum is avoidably wasted. In 2014, The Lancet published a series of five reviews showing how dividends from the investment in research might be increased from the relevance and priorities of the questions being asked, to how the research is designed, conducted, and reported. 17 recommendations were addressed to five main stakeholders-funders, regulators, journals, academic institutions, and researchers. This Review provides some initial observations on the possible effects of the Series, which seems to have provoked several important discussions and is on the agendas of several key players. Some examples of individual initiatives show ways to reduce waste and increase value in biomedical research. This momentum will probably move strongly across stakeholder groups, if collaborative relationships evolve between key players; further important work is needed to increase research value. A forthcoming meeting in Edinburgh, UK, will provide an initial forum within which to foster the collaboration needed.
DOI: 10.1016/S0140-6736(15)00307-4
PubMed: 26423180
Affiliations:
- Australie, Canada, France, Pays-Bas, Royaume-Uni
- Angleterre, Hollande-Septentrionale, Oxfordshire, Île-de-France
- Amsterdam, Oxford, Paris
- Université d'Amsterdam
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Le document en format XML
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Electronic address: dmoher@ohri.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, ON, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Glasziou, Paul" sort="Glasziou, Paul" uniqKey="Glasziou P" first="Paul" last="Glasziou">Paul Glasziou</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Research in Evidence Based Practice, Bond University, Robina, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Research in Evidence Based Practice, Bond University, Robina, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, Iain" sort="Chalmers, Iain" uniqKey="Chalmers I" first="Iain" last="Chalmers">Iain Chalmers</name><affiliation wicri:level="3"><nlm:affiliation>James Lind Initiative, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>James Lind Initiative, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Nasser, Mona" sort="Nasser, Mona" uniqKey="Nasser M" first="Mona" last="Nasser">Mona Nasser</name><affiliation wicri:level="1"><nlm:affiliation>Peninsula Dental School, Plymouth University, Plymouth, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Peninsula Dental School, Plymouth University, Plymouth</wicri:regionArea><wicri:noRegion>Plymouth</wicri:noRegion></affiliation></author><author><name sortKey="Bossuyt, Patrick M M" sort="Bossuyt, Patrick M M" uniqKey="Bossuyt P" first="Patrick M M" last="Bossuyt">Patrick M M. Bossuyt</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Korevaar, Daniel A" sort="Korevaar, Daniel A" uniqKey="Korevaar D" first="Daniël A" last="Korevaar">Daniël A. Korevaar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Graham, Ian D" sort="Graham, Ian D" uniqKey="Graham I" first="Ian D" last="Graham">Ian D. Graham</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, ON, Ottawa, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, ON, Ottawa</wicri:regionArea><wicri:noRegion>Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name><affiliation wicri:level="3"><nlm:affiliation>METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, UMR 1153, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, UMR 1153, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Boutron, Isabelle" sort="Boutron, Isabelle" uniqKey="Boutron I" first="Isabelle" last="Boutron">Isabelle Boutron</name><affiliation wicri:level="3"><nlm:affiliation>METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, UMR 1153, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>METHODS Team, Centre of Research in Epidemiology and Statistics Sorbonne Paris Cité, UMR 1153, Institut National de la Santé et de la Recherche Médicale, University Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomedical Research (standards)</term><term>Cooperative Behavior</term><term>Humans</term><term>Research Design (standards)</term><term>Research Personnel</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Comportement coopératif</term><term>Humains</term><term>Personnel de recherche</term><term>Plan de recherche (normes)</term><term>Recherche biomédicale (normes)</term></keywords><keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Plan de recherche</term><term>Recherche biomédicale</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Biomedical Research</term><term>Research Design</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cooperative Behavior</term><term>Humans</term><term>Research Personnel</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Comportement coopératif</term><term>Humains</term><term>Personnel de recherche</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The biomedical research complex has been estimated to consume almost a quarter of a trillion US dollars every year. Unfortunately, evidence suggests that a high proportion of this sum is avoidably wasted. In 2014, The Lancet published a series of five reviews showing how dividends from the investment in research might be increased from the relevance and priorities of the questions being asked, to how the research is designed, conducted, and reported. 17 recommendations were addressed to five main stakeholders-funders, regulators, journals, academic institutions, and researchers. This Review provides some initial observations on the possible effects of the Series, which seems to have provoked several important discussions and is on the agendas of several key players. Some examples of individual initiatives show ways to reduce waste and increase value in biomedical research. This momentum will probably move strongly across stakeholder groups, if collaborative relationships evolve between key players; further important work is needed to increase research value. A forthcoming meeting in Edinburgh, UK, will provide an initial forum within which to foster the collaboration needed.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Hollande-Septentrionale</li><li>Oxfordshire</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Oxford</li><li>Paris</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Moher, David" sort="Moher, David" uniqKey="Moher D" first="David" last="Moher">David Moher</name></noRegion><name sortKey="Graham, Ian D" sort="Graham, Ian D" uniqKey="Graham I" first="Ian D" last="Graham">Ian D. Graham</name></country><country name="Australie"><noRegion><name sortKey="Glasziou, Paul" sort="Glasziou, Paul" uniqKey="Glasziou P" first="Paul" last="Glasziou">Paul Glasziou</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Chalmers, Iain" sort="Chalmers, Iain" uniqKey="Chalmers I" first="Iain" last="Chalmers">Iain Chalmers</name></region><name sortKey="Nasser, Mona" sort="Nasser, Mona" uniqKey="Nasser M" first="Mona" last="Nasser">Mona Nasser</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Bossuyt, Patrick M M" sort="Bossuyt, Patrick M M" uniqKey="Bossuyt P" first="Patrick M M" last="Bossuyt">Patrick M M. Bossuyt</name></region><name sortKey="Korevaar, Daniel A" sort="Korevaar, Daniel A" uniqKey="Korevaar D" first="Daniël A" last="Korevaar">Daniël A. Korevaar</name></country><country name="France"><region name="Île-de-France"><name sortKey="Ravaud, Philippe" sort="Ravaud, Philippe" uniqKey="Ravaud P" first="Philippe" last="Ravaud">Philippe Ravaud</name></region><name sortKey="Boutron, Isabelle" sort="Boutron, Isabelle" uniqKey="Boutron I" first="Isabelle" last="Boutron">Isabelle Boutron</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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